Which group of patients may have a reduced response to ACE inhibitors?

Elderly patients with low renin levels may exhibit a reduced response to ACE inhibitors due to several physiological changes associated with aging and the disease processes they often experience. As individuals age, there tends to be a decrease in the renin-angiotensin-aldosterone system's activity, leading to lower levels of renin production. The efficacy of ACE inhibitors relies on the inhibition of the angiotensin-converting enzyme, which is part of this system. When renin levels are low, the activation of this pathway is diminished, reducing the potential therapeutic benefits of ACE inhibitors.

In this context, elderly patients are more likely to have comorbidities and medications that also affect the renin-angiotensin system, further complicating the response to ACE inhibitors. Understanding these nuances helps clinicians anticipate and manage therapy outcomes better.